McCay's hypothesis: undernutrition and longevity

McCay's hypothesis: undernutrition and longevity.

Clive McCay et al. (1935) reported a seminal study which showed that reducing the amount of food of rats starting at or soon after weaning to well below that eaten by ad lib.-fed rats resulted in an increase in the length of life. They hypothesized that this increase in longevity is due to the retardation of growth. In the ensuing years, the life-extending effect of reducing food intake has bee...

Hypothesis: pulse pressure and human longevity.

In exploration of the association between pulse pressure and longevity in humans, 3 hypotheses are briefly discussed: the fetal origin hypothesis, antagonistic pleiotropy, and the telomere hypothesis of cellular aging. The implications of these hypotheses serve to draw a critical distinction between biologic age (aging) and chronological age and, thereby, offer an answer to a question that pres...

Telomeres and longevity: testing an evolutionary hypothesis.

Identifying mechanisms that underlie variation in adult survivorship provide insight into the evolution of life history strategies and phenotypic variation in longevity. There is accumulating evidence that shortening telomeres, the protective caps at the ends of chromosomes, play an important role in individual variation in longevity. Given that telomeres generally shorten with age, it was surp...

Beyond the Grandmother Hypothesis: Evolutionary Models of Human Longevity

Calorie Restriction, Longevity and Cognitive Function